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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：205911
- cas：1231929-97-7
- 發(fā)布日期： 2022-11-10
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 205911 |
| 用途 | 科研 |
| 包裝規(guī)格 | 10mg;100mg;200mg;500mg;1g;2g;5g |
| CAS編號(hào) | 1231929-97-7 |
| 純度 | >98% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：玻瑪西尼，也稱為L(zhǎng)Y2835219，是一種口服的細(xì)胞周期蛋白依賴性激酶（CDK）抑制劑，靶向CDK4（細(xì)胞周期蛋白D1）和CDK6（細(xì)胞周期素D3）細(xì)胞周期途徑，具有潛在的抗腫瘤活性。LY2835219以低納摩爾效力抑制CDK4和CDK6。LY2835219特異性抑制CDK4和6，從而抑制G1早期的視網(wǎng)膜母細(xì)胞瘤（Rb）蛋白磷酸化。抑制Rb磷酸化阻止CDK介導(dǎo)的G1-S期轉(zhuǎn)變，從而阻止G1期的細(xì)胞周期，抑制DNA合成并抑制癌細(xì)胞生長(zhǎng)。
產(chǎn)品名稱: Abemaciclib free base
CAS#: 1231929-97-7 (free base)
分子式: C27H32F2N8
Exact Mass: 506.2718
分子量: 506.59
元素分析: C, 64.01; H, 6.37; F, 7.50; N, 22.12
Synonym: LY2835219; LY2835219; LY 2835219; Abemaciclib.
IUPAC/Chemical Name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
InChi Key: UZWDCWONPYILKI-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
SMILES Code: CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0-4 C for short term (weeks), and -20 C for long term (months)
HS Tariff Code: 2934.99.9001
