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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：206112
- cas：1420477-60-6
- 發(fā)布日期： 2022-11-10
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 206112 |
| 用途 | 科研 |
| 包裝規(guī)格 | 50mg;100mg;200mg;500mg;1g;2g |
| CAS編號(hào) | 1420477-60-6 |
| 純度 | >98% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：阿卡替尼，也稱為ACP-196，是一種口服的布魯頓酪氨酸激酶（BTK）抑制劑，具有潛在的抗腫瘤活性。給藥后，ACP-196抑制BTK的活性并阻止B細(xì)胞抗原受體（BCR）信號(hào)通路的激活。這防止了B細(xì)胞激活和BTK介導(dǎo)的下游生存途徑的激活。這導(dǎo)致抑制過表達(dá)BTK的惡性B細(xì)胞的生長(zhǎng)。BTK是src相關(guān)的細(xì)胞質(zhì)酪氨酸激酶BTK/Tec家族的成員，在B細(xì)胞惡性腫瘤中過表達(dá)；它在B淋巴細(xì)胞的發(fā)育、活化、信號(hào)傳導(dǎo)、增殖和存活中起重要作用。
產(chǎn)品名稱: Acalabrutinib (ACP-196)
CAS#: 1420477-60-6 (free base)
分子式: C26H23N7O2
Exact Mass: 465.19132
分子量: 465.52
元素分析: C, 67.08; H, 4.98; N, 21.06; O, 6.87
Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib
IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N
InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
