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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：202271
- cas：918504-65-1
- 價格： ￥5/毫克
- 發(fā)布日期： 2022-11-10
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 202271 |
| 用途 | 科研 |
| 包裝規(guī)格 | 200mg;500mg;1g;2g;5g |
| CAS編號 | 918504-65-1 |
| 純度 | >98%% |
| 是否進口 | 是 |
產(chǎn)品描述：維羅非尼也稱為PLX4032、RG7204或RO5185426，是一種口服生物利用性、ATP競爭性的BRAF（V600E）激酶小分子抑制劑，具有潛在的抗腫瘤活性。Vemurafenib于2011年8月17日獲得FDA批準用于 晚期黑色素瘤。Vemuraffenib選擇性地結(jié)合BRAF（V600E）激酶的ATP結(jié)合位點并抑制其活性，這可能導致抑制表達BRAF的腫瘤細胞下游過度激活的MAPK信號通路并降低腫瘤細胞增殖。
產(chǎn)品名稱: Vemurafenib
CAS#: 918504-65-1
分子式: C23H18ClF2N3O3S
Exact Mass: 489.07255
分子量: 489.92
元素分析: C, 56.39; H, 3.70; Cl, 7.24; F, 7.76; N, 8.58; O, 9.80; S, 6.54
Synonym: PLX4032; PLX 4032; PLX-4032; RG7204 ; RG7204 ; RG 7204 ; RO5185426; RO 5185426 RO5185426 Vemurafenib; Brand name: Zelboraf
IUPAC/Chemical Name: N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
InChi Key: GPXBXXGIAQBQNI-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
SMILES Code: CCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(C4=CC=C(Cl)C=C4)C=C32)=O)=C1F)=O
Appearance: White to off-white crystalline solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
