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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：200560
- cas：380843-75-4
- 發(fā)布日期： 2022-11-09
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 200560 |
| 用途 | 科研 |
| 包裝規(guī)格 | 10mg;25mg;50mg;100mg;200mg |
| CAS編號 | 380843-75-4 |
| 純度 | >98% |
| 是否進口 | 是 |
產(chǎn)品描述：伯舒替尼，也稱為SKI-606，是一種合成的喹諾酮衍生物和雙激酶抑制劑，靶向具有潛在抗腫瘤活性的Abl和Src激酶。與伊馬替尼不同，博蘇替尼抑制Abl和Src激酶的自磷酸化，從而抑制細胞生長和凋亡。由于其雙重作用機制，該藥物可能在耐藥CML疾病、其他髓系惡性腫瘤和實體瘤中具有活性。Abl激酶在異常Bcr-Abl融合蛋白的存在下上調(diào)，該蛋白通常與慢性粒細胞白血?。–ML）相關(guān)。特異性Src激酶的過度表達也與伊馬替尼耐藥CML表型相關(guān)。博蘇替尼于2012年獲批。
產(chǎn)品名稱: Bosutinib
CAS#: 380843-75-4 (free base)
分子式: C26H29Cl2N5O3
分子量: 530.44
元素分析: C, 58.87; H, 5.51; Cl, 13.37; N, 13.20; O, 9.05
Synonym: SKI606; SKI 606; SK-I606. SK 606; SK-606; SK606; KIN 001-160; KIN001-160; KIN-001-160; KIN 001160; KIN-001160; KIN001160; Bosutinib; Brand name: Bosulif.
IUPAC/Chemical Name: 4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
InChi Key: UBPYILGKFZZVDX-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
SMILES Code: N#CC1=C(NC2=CC(OC)=C(Cl)C=C2Cl)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1
Appearance: Pale yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
