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- 品牌：Ansh Labs
- 產(chǎn)地：國(guó)外
- 型號(hào)：25μL
- 貨號(hào)：AL-120
- 發(fā)布日期： 2022-08-25
- 更新日期： 2024-08-12
| 產(chǎn)地 | 國(guó)外 |
| 保存條件 | 詳詢 |
| 品牌 | Ansh Labs |
| 貨號(hào) | AL-120 |
| 用途 | 詳詢 |
| 檢測(cè)方法 | 詳詢 |
| CAS編號(hào) | |
| 保質(zhì)期 | 詳詢 |
| 適應(yīng)物種 | 詳詢 |
| 檢測(cè)限 | 詳詢 |
| 數(shù)量 | 詳詢 |
| 包裝規(guī)格 | 25μL |
| 標(biāo)記物 | 詳詢 |
| 純度 | 詳詢% |
| 樣本 | 詳詢 |
| 應(yīng)用 | 詳詢 |
| 是否進(jìn)口 | 是 |
Product Description：Insulin-like growth factor binding protein-3 (IGFBP-3) is a 264-amino acid peptide (MW 29 kD) produced by the liver. It is the most abundant of a group of IGFBPs that transport, and control bioavailability and half-life of insulin-like growth factors (IGF), in particular IGF-1, the major mediator of the anabolic- and growth-promoting effects of growth hormone (GH). The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II, thus prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Most of the IGFBP-3 in plasma is present as the high molecular weight ternary complex, however, small amounts of free IGFBP-3 are also found.
IGFBP-3 also exhibits intrinsic growth-regulating effects that are not yet fully understood, but have evoked interest with regards to a possible role of IGFBP-3 as a prognostic tumor marker. Low IGFBP-3 and IGF-1 levels are observed in GH deficiency or GH resistance, also epidemiologic studies suggest that low IGFBP-3 is associated with greater risk of aggressive, metastatic prostate cancers. The elevated serum IGFBP-3 and IGF-1 levels indicate a sustained overproduction of GH, or excessive rhGH therapy. Both conditions are associated with generalized organomegaly, hypertension, diabetes, cardiomyopathy, osteoarthritis, and diminished longevity.
The Ansh Labs Total IGFBP-3 Assay uses an acidification and neutralization method to dissociate IGFBP-3 from all the binding subunits. Total IGFBP-3 levels are quantified in the extracted samples using a highly sensitive and specific total IGFBP-3 ELISA. Similarly Intact IGFBP-3 levels can be measured using Intact IGFBP-3 ELISA (AL-149).
Regulatory Status：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Packaging：96 well microtiter
Detection：HRP-based ELISA, colorimetric detection by dual wavelength absorbance at 450 nm and 630 nm as reference filter
Dynamic Range：6, 7.5-216 ng/mL
Limit of Detection：0.3 ng/mL
Sample Type：Serum
Assay Time：1.5 hours
Species Reactivity：Human
Shelf Life：24 months
