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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：205807
- cas：1257044-40-8
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 205807 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g; 50.0g; |
| CAS編號 | 1257044-40-8 |
| 純度 | >98%% |
| 是否進口 | 是 |
產(chǎn)品描述：維奈妥拉也稱為ABT-199或GDC0199，是一種口服生物可利用的抗凋亡蛋白Bcl-2的選擇性小分子抑制劑，具有潛在的抗腫瘤活性。Venetoclax通過與Bcl-2蛋白的疏水溝結(jié)合，從而抑制Bcl-2活性并恢復(fù)腫瘤細胞中的凋亡過程，從而模擬僅BH3蛋白（Bcl-2和凋亡激活劑的天然配體）。
產(chǎn)品名稱: Venetoclax (ABT199)
CAS#: 1257044-40-8
分子式: C45H50ClN7O7S
分子量: 868.44
元素分析: C, 62.24; H, 5.80; Cl, 4.08; N, 11.29; O, 12.90; S, 3.69
Synonym: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601. Venetoclax; Venclexta;
IUPAC/Chemical Name: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
InChi Key: LQBVNQSMGBZMKD-UHFFFAOYSA-N
InChi Code: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)
SMILES Code: O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
