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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：205513
- cas：1211441-98-3
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 205513 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g; |
| CAS編號(hào) | 1211441-98-3 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: 瑞博西尼，也稱為L(zhǎng)EE011，是一種口服的細(xì)胞周期蛋白依賴性激酶（CDK）抑制劑，靶向細(xì)胞周期蛋白D1/CDK4和細(xì)胞周期蛋白D3/CDK6細(xì)胞周期途徑，具有潛在的抗腫瘤活性。CDK4/6抑制劑LEE011特異性地抑制CDK4和6，從而抑制視網(wǎng)膜母細(xì)胞瘤（Rb）蛋白磷酸化。抑制Rb磷酸化阻止CDK介導(dǎo)的G1-S期轉(zhuǎn)變，從而阻止G1期的細(xì)胞周期，抑制DNA合成并抑制癌細(xì)胞生長(zhǎng)。在某些類型的癌癥中，CDK4/6的過度表達(dá)會(huì)導(dǎo)致細(xì)胞周期失調(diào)。
產(chǎn)品名稱: Ribociclib Free Base
CAS#: 1211441-98-3 (free base)
分子式: C23H30N8O
Exact Mass: 434.25426
分子量: 434.54
元素分析: C, 63.57; H, 6.96; N, 25.79; O, 3.68
Synonym: LEE011; LEE-011. LEE 011; Ribociclib; Kisqali.
IUPAC/Chemical Name: 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
InChi Key: RHXHGRAEPCAFML-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
SMILES Code: O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
