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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：202436
- cas：755037-03-7
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 202436 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g; 50.0g; |
| CAS編號(hào) | 755037-03-7 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述: 瑞格非尼，又名BAY 73-4506；是一種口服生物利用的小分子，具有潛在的抗血管生成和抗腫瘤活性。瑞戈非尼結(jié)合并抑制血管內(nèi)皮生長(zhǎng)因子受體（VEGFR）2和3以及Ret、Kit、PDGFR和Raf激酶，這可能導(dǎo)致抑制腫瘤血管生成和腫瘤細(xì)胞增殖。雷戈非尼證明可以提高轉(zhuǎn)移性結(jié)直腸癌患者的總體生存率，并于2012年9月27日獲得美國(guó)FDA的批準(zhǔn)。
產(chǎn)品名稱: Regorafenib
CAS#: 755037-03-7
分子式: C21H15ClF4N4O3
分子量: 482.81541
元素分析: C, 52.24; H, 3.13; Cl, 7.34; F, 15.74; N, 11.60; O, 9.94
Synonym: BAY 734506; BAY734506; BAY-734506; Regorafenib. trade name: Stivarga.
IUPAC/Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
InChi Key: ZFLJHSQHILSNCM-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
SMILES Code: C12=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC(NC5CCCCC5)=C1NC=N2
Appearance: Off-white to light pink solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
