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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：100952
- cas：641571-10-0
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 100952 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 500mg;1g;2g;5g;10g;50g;1kg |
| CAS編號(hào) | 641571-10-0 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：尼羅替尼，也稱(chēng)為AMN107，是一種小分子酪氨酸激酶抑制劑，被批準(zhǔn)用于 伊馬替尼耐藥的慢性粒細(xì)胞白血病。在結(jié)構(gòu)上與伊馬替尼有關(guān)，它是基于Abl-伊馬替尼復(fù)合物的結(jié)構(gòu)開(kāi)發(fā)的，以解決伊馬替尼克不耐受和耐藥性。尼羅替尼是一種選擇性Bcr-Abl激酶抑制劑，在抑制Bcr-Alb酪氨酸激酶活性和Bcr-Abl表達(dá)細(xì)胞增殖方面比伊馬替尼強(qiáng)10-30倍。諾利替尼由諾華公司開(kāi)發(fā)，以商品名Tasigna出售。
產(chǎn)品名稱(chēng): Nilotinib free base
CAS#: 641571-10-0 (free base)
分子式 C28H22F3N7O
分子量: 529.53
元素分析: C, 63.51; H, 4.19; F, 10.76; N, 18.52; O, 3.02
Synonym: Nilotinib free base; AMN 107; AMN107; AMN-107; Nilotinib; US brand name: Tasigna.
IUPAC/Chemical Name: 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-{(4-(pyridin-3-yl)pyrimidin-2-yl)amino}benzamide
InChi Key: HHZIURLSWUIHRB-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
