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Pexidartinib (PLX3397) 吡昔替尼 1029044-16-3
  • 品牌:MedKoo
  • 產(chǎn)地:美國
  • 貨號(hào):206178
  • cas:1029044-16-3
  • 發(fā)布日期: 2022-07-20
  • 更新日期: 2024-08-12
產(chǎn)品詳請(qǐng)
產(chǎn)地 美國
品牌 MedKoo
貨號(hào) 206178
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g;
CAS編號(hào) 1029044-16-3
純度 >98%%
是否進(jìn)口

產(chǎn)品描述:吡昔替尼,也稱為PLX-3397,是一種CSF1R抑制劑,Plexxikon正在開發(fā)IC50為20nM,用于 腱膜巨細(xì)胞瘤。它正在進(jìn)行色素性絨毛結(jié)節(jié)性滑膜炎(PVNS)或肌腱鞘巨細(xì)胞瘤(GCT-TS)的3期臨床試驗(yàn)。

產(chǎn)品名稱: Pexidartinib (PLX3397)
CAS#: 1029044-16-3 (free base)
分子式: C20H15ClF3N5
Exact Mass: 417.09681
分子量: 417.81
元素分析: C, 57.49; H, 3.62; Cl, 8.49; F, 13.64; N, 16.76


Synonym: PLX3397; PLX-3397; PLX 3397; CML-261; CML 261; CML261; FP-113; FP 113; FP113; Pexidartinib; Turalio

IUPAC/Chemical Name: 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

InChi Key: JGWRKYUXBBNENE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)

SMILES Code: FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO (20mg/ mL), not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001