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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：201470
- cas：698387-09-6
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 201470 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g; |
| CAS編號 | 698387-09-6 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：來那替尼也稱為HKI-272或PB272，是一種口服的、不可逆的HER-2受體酪氨酸激酶抑制劑，具有潛在的抗腫瘤活性。奈拉替尼不可逆地與HER-2受體結(jié)合，從而減少細(xì)胞中的自磷酸化，顯然是通過靶向受體ATP結(jié)合袋中的半胱氨酸殘基。
產(chǎn)品名稱: Neratinib
CAS#: 698387-09-6 (free base)
分子式: C30H29ClN6O3
Exact Mass: 556.19897
分子量: 557.04
元素分析: C, 64.68; H, 5.25; Cl, 6.36; N, 15.09; O, 8.62
Synonym: HKI272; HKI 272; HKI-272; PB272; PB 272; PB-272; Neratinib; Nerlynx
IUPAC/Chemical Name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
InChi Key: JWNPDZNEKVCWMY-VQHVLOKHSA-N
InChi Code: InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
SMILES Code: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
