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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號(hào)：100490A
- cas：231277-92-2
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號(hào) | 100490A |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; 20.0g; |
| CAS編號(hào) | 231277-92-2 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：拉帕替尼是一種合成的口服活性喹唑啉，具有潛在的抗腫瘤活性。拉帕替尼可逆地阻斷表皮生長因子受體（EGFR）、ErbB2、Erk-1和2以及AKT激酶的磷酸化；它還抑制人腫瘤細(xì)胞系和異種移植物中的細(xì)胞周期蛋白D蛋白水平。EGFR和ErbB2與各種腫瘤類型的生長有關(guān)。檢查使用該藥劑的活躍臨床試驗(yàn)或封閉臨床試驗(yàn)。
產(chǎn)品名稱: Lapatinib (free base)
CAS#: 231277-92-2 (free base)
分子式: C29H26ClFN4O4S
Exact Mass: 580.13473
分子量: 581.06
元素分析: C, 59.94; H, 4.51; Cl, 6.10; F, 3.27; N, 9.64; O, 11.01; S, 5.52
Synonym: GSK572016; GSK-572016; GSK 572016; GW2016; GW-2016; GW 2016; Lapatinib. US brand name: Tykerb.
IUPAC/Chemical Name: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine
InChi Key: BCFGMOOMADDAQU-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
SMILES Code: O=S(CCNCC1=CC=C(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)O1)(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
