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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：100470
- cas：152459-95-5
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 100470 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 2.0g; 5.0g; 10.0g; 20.0g; 50.0g; 100.0g; 200.0g; 500.0g; |
| CAS編號(hào) | 152459-95-5 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：伊馬替尼是一種具有抗cancer活性的酪氨酸激酶抑制劑。伊馬替尼與位于酪氨酸激酶（TK）內(nèi)的細(xì)胞內(nèi)袋結(jié)合，從而抑制ATP結(jié)合，防止磷酸化和隨后的生長(zhǎng)受體及其下游信號(hào)轉(zhuǎn)導(dǎo)途徑的激活。該藥劑抑制PDGFR癌基因編碼受體TK。伊馬替尼于2001年在美國(guó)被批準(zhǔn)用于醫(yī)療用途。
產(chǎn)品名稱: Imatinib free base
CAS#: 152459-95-5 (free base)
分子式: C29H31N7O
分子量: 493.615
元素分析: C, 70.56; H, 6.33; N, 19.86; O, 3.24
Synonym: CGP 57148; CGP57148; CGP-57148; CGP57148B; CGP-57148B; CGP 57148B; STI571; STI-571; STI 571; Imatinib; US brand name: Gleevec. Foreign brand name: Glivec
IUPAC/Chemical Name: N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
InChi Key: KTUFNOKKBVMGRW-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
SMILES Code: O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4
Appearance: white to off-white to brownish or yellowish tinged crystalline powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
