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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：206139
- cas：1254053-43-4
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 206139 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; |
| CAS編號 | 1254053-43-4 |
| 純度 | >98%% |
| 是否進口 | 是 |
產(chǎn)品描述：吉列替尼，也稱為ASP2215，是一種有效的FLT3/AXL抑制劑，對FLT3-ITD和FLT3-D835突變的AML表現(xiàn)出有效的抗白血病活性。在體外，在測試的78種酪氨酸激酶中，ASP2215在1nM時抑制FLT3、LTK、ALK和AXL激酶超過50%，F(xiàn)LT3的IC50值為0.29nM，大約比c-KIT強800倍，其抑制與骨髓抑制的潛在風(fēng)險有關(guān)。ASP2215抑制攜帶FLT3-ITD的MV4-11細胞的生長，IC50值為0.92nM，同時抑制pFLT3、pAKT、pSTAT5、pERK和pS6。ASP2215可能在 AML中有潛在用途。
產(chǎn)品名稱: Gilteritinib
CAS#: 1254053-43-4 (free base)
分子式: C29H44N8O3
Exact Mass: 552.35364
分子量: 552.71
元素分析: C, 63.02; H, 8.02; N, 20.27; O, 8.68
Synonym: ASP-2215; ASP2215; ASP 2215; Gilteritinib.
IUPAC/Chemical Name: 6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide.
InChi Key: GYQYAJJFPNQOOW-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)
SMILES Code: O=C(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C(OC)=C3)N
Appearance: Yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
