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- 品牌：MedKoo
- 產(chǎn)地：美國(guó)
- 貨號(hào)：205576
- cas：1110813-31-4
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國(guó) |
| 品牌 | MedKoo |
| 貨號(hào) | 205576 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 50.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g; 10.0g; |
| CAS編號(hào) | 1110813-31-4 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：達(dá)克替尼，也稱為PF-299和PF-00299804；PF299804是酪氨酸激酶（ErbB家族）泛表皮生長(zhǎng)因子受體（EGFR）家族的一種口服生物可利用、高選擇性的 代小分子抑制劑，具有潛在的抗腫瘤活性。達(dá)科替尼特異性且不可逆地結(jié)合并抑制人EGFR亞型，導(dǎo)致抑制EGFR表達(dá)腫瘤細(xì)胞的增殖和誘導(dǎo)凋亡。EGFR在腫瘤細(xì)胞增殖和腫瘤血管形成中起主要作用，并且在各種腫瘤細(xì)胞類型中經(jīng)常過(guò)度表達(dá)或突變。
產(chǎn)品名稱: Dacomitinib
CAS#: 1110813-31-4 (free)
分子式: C24H25ClFN5O2
Exact Mass: 469.16808
分子量: 469.94
元素分析: C, 61.34; H, 5.36; Cl, 7.54; F, 4.04; N, 14.90; O, 6.81
Synonym: PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF299; PF 299; Dacomitinib; Vizimpro;
IUPAC/Chemical Name: (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
InChi Key: LVXJQMNHJWSHET-AATRIKPKSA-N
InChi Code: InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
SMILES Code: O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
