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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：205479
- cas：1195765-45-7
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 205479 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 25mg;50mg;100mg;500mg |
| CAS編號 | 1195765-45-7 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：達(dá)帕菲尼，也稱為GSK2118436，是一種口服生物可利用的B-raf（BRAF）蛋白抑制劑，具有潛在的抗腫瘤活性。達(dá)帕菲尼選擇性地結(jié)合并抑制B-raf的活性，B-raf可以抑制含有突變BRAF基因的腫瘤細(xì)胞的增殖。B-raf屬于絲氨酸/蘇氨酸蛋白激酶的raf/mil家族，在調(diào)節(jié)MAP激酶/ERKs信號通路中發(fā)揮作用，該通路可能由于BRAF基因突變而被組成性激活。2013年5月29日，F(xiàn)DA批準(zhǔn)了該藥物。
產(chǎn)品名稱: Dabrafenib
CAS#: 1195765-45-7 (free base)
分子式: C23H20F3N5O2S2
Exact Mass: 519.10105
分子量: 519.56
元素分析: C, 53.17; H, 3.88; F, 10.97; N, 13.48; O, 6.16; S, 12.34
Synonym: GSK2118436A ( Dabrafenib ); GSK 2118436A; GSK-2118436A; GSK2118436B ( Dabrafenib Mesylate ); GSK-2118436B; GSK 2118436B. Trade name: Tafinlar.
IUPAC/Chemical Name: N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
InChi Key: BFSMGDJOXZAERB-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
SMILES Code: O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
