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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：530444
- cas：1402612-55-8
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 530444 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 5.0mg; 25.0mg; |
| CAS編號 | 1402612-55-8 |
| 純度 | >98%% |
| 是否進口 | 是 |
Description: KT109 is a selective inhibitor of DAGLβ with an IC50 value of 42 nM. DAGL-β (-/-) mice or KT109-treated wild-type mice displayed reductions in LPS-induced allodynia. Repeated KT109 administration prevented the expression of LPS-induced allodynia, without evidence of tolerance. Intraplantar injection of KT109 into the LPS-treated paw, but not the contralateral paw, reversed the allodynic responses. KT109 also reversed allodynia in the CCI and CINP models and lacked discernible side effects (e.g. gross motor deficits, anxiogenic behaviour or gastric ulcers).
Name: KT109
CAS#: 1402612-55-8
Chemical Formula: C27H26N4O
Exact Mass: 422.2107
Molecular Weight: 422.532
Elemental Analysis: C, 76.75; H, 6.20; N, 13.26; O, 3.79
Synonym: KT109; KT-109; KT 109
IUPAC/Chemical Name: (4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[2-(phenylmethyl)-1-piperidinyl]-methanone
InChi Key: JKJMWHULJIOKPJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2
SMILES Code: O=C(N1N=NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)N4C(CC5=CC=CC=C5)CCCC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO (10mg/mL)
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
