|
- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號：205852
- cas：1269440-17-6
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號 | 205852 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; |
| CAS編號 | 1269440-17-6 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
產(chǎn)品描述：康奈非尼，也稱為LGX-818，是一種口服Raf激酶抑制劑，具有潛在的抗腫瘤活性。LGX818特異性抑制Raf激酶，一種Raf/絲裂原激活蛋白激酶（MEK）/細(xì)胞外信號相關(guān)激酶（ERK）信號通路中的絲氨酸/蘇氨酸酶。通過抑制RAF/MEK/ERK信號通路的激活，LGX818的施用可能導(dǎo)致腫瘤細(xì)胞增殖的減少。
產(chǎn)品名稱: Encorafenib
CAS#: 1269440-17-6
分子式: C22H27ClFN7O4S
Exact Mass: 539.15178
分子量: 540.01
元素分析: C, 48.93; H, 5.04; Cl, 6.57; F, 3.52; N, 18.16; O, 11.85; S, 5.94
Synonym: LGX818; LGX-818; LGX 818; Encorafenib.
IUPAC/Chemical Name: (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate.
InChi Key: CMJCXYNUCSMDBY-ZDUSSCGKSA-N
InChi Code: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1
SMILES Code: O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
